SportsLine's model simulated Notre Dame Fighting Irish vs. Ohio State Buckeyes in the 2025 CFP National Championship game 10,000 times

Penn State was unable to corral Oregon’s offense in the Big Ten Championship though, allowing 496 total yards while dropping a 45-37 decision to the then undefeated Ducks. The Nittany Lions eviscerated SMU in the first round of the CFP Playoff,

Notre Dame and Penn State are set for the College Football Playoff Orange Bowl semifinal with a shot at the national title matchup on the line. Here’s the latest prediction for the game from an expert analytical model that projects scores and picks winners.