A variant of the virus caused disease in people in 1997, when there was a small but deadly outbreak in Hong Kong. Eighteen people had confirmed diagnoses, and six of them died. Since then, there have been sporadic cases around the world—but no large outbreaks.

With reports of the first human death from bird flu in the US, some Americans are feeling an uncomfortable flashback to the early days of Covid-19, when infectious disease experts were talking about a new virus that was sending people to the hospital with respiratory infections.

Two months shy of the fifth anniversary of COVID-19 being declared a global pandemic, the US has recorded its first human death as a result of avian influenza H5N1 infection. The unidentified Louisiana man contracted the virus through contact with infected wild and domestic birds on his property